Cover Feature: Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane (ChemPhysChem 20/2018)

Highly enantioselective addition of phenylethynylzinc to aldehydes catalyzed by chiral cyclopropane-based amino alcohols.

The enantioselective addition of phenylethynylzinc to aldehydes catalyzed by a series of cyclopropane-based amino alcohol ligands 7 was investigated. The reactions afforded chiral propargylic alcohols in high yields (up to 96%) and with excellent enantioselectivities (up to 98% ee) under mild conditions. Furthermore, studies on the structural relationship show that the matching of the chiral ce...

Cover Feature Outlook

Cover Feature Physiological Computing

Brain−computer interfaces (BCIs) hold great promise for improving information delivery and preserving user attention, but this promise has not yet translated to practical use. A prototype BCI that optimizes email notifications in noisy, complex environments, CARSON combines multiple measures from the brain to predict both cognitive workload and message relevancy to determine the optimum time to...

Cover Feature Software Engineering

Cover Feature Big Data

Today’s applications often contain datasets that are too big to fit in a single computer’s main memory. Analyzing these massive datasets will require scalable and sophisticated machine-learning methods. Two commonly used approaches are stochastic optimization and inference algorithms,1 which process one data point at a time; and distributed computing based on the MapReduce framework,2 where the...